4ESR

Molecular and Structural Characterization of the SH3 Domain of AHI-1 in Regulation of Cellular Resistance of BCR-ABL+ Chronic Myeloid Leukemia Cells to Tyrosine Kinase Inhibitors

4ESR の概要

• エントリーDOI: 10.2210/pdb4esr/pdb
• 分子名称: Jouberin, DI(HYDROXYETHYL)ETHER (3 entities in total)
• 機能のキーワード: ahi-1, ahi1, ahi-1 sh3 domain, sh3 domain, dynamin-2, protein binding, chronic myeloid leukemia
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton, cilium basal body : Q8N157
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 16227.67

構造登録者

Van Petegem, X.F.,Liu, P.X.,Lobo, P.,Jiang, X. (登録日: 2012-04-23, 公開日: 2012-06-06, 最終更新日: 2024-02-28)

• 主引用文献: Liu, X.,Chen, M.,Lobo, P.,An, J.,Grace Cheng, S.W.,Moradian, A.,Morin, G.B.,Van Petegem, F.,Jiang, X.; Molecular and structural characterization of the SH3 domain of AHI-1 in regulation of cellular resistance of BCR-ABL(+) chronic myeloid leukemia cells to tyrosine kinase inhibitors.; Proteomics, 12:2094-2106, 2012; PubMed: 22623184; DOI: 10.1002/pmic.201100553

実験手法

X-RAY DIFFRACTION (1.53 Å)