4ESP

Crystal Structure of Peanut Allergen Ara h 5

4ESP の概要

• エントリーDOI: 10.2210/pdb4esp/pdb
• 分子名称: Profilin, 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, ... (4 entities in total)
• 機能のキーワード: peanut allergen, allergy, ara h 5, profilin, allergen
• 由来する生物種: Arachis hypogaea (goober,ground-nut)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14600.55

構造登録者

Wang, Y.,Zhang, Y.Z. (登録日: 2012-04-23, 公開日: 2013-03-06, 最終更新日: 2024-02-28)

主引用文献

Wang, Y.,Fu, T.J.,Howard, A.,Kothary, M.H.,McHugh, T.H.,Zhang, Y.
Crystal Structure of Peanut ( Arachis hypogaea ) Allergen Ara h 5.
J.Agric.Food Chem., 61:1573-1578, 2013

PubMed Abstract: Profilins from numerous species are known to be allergens, including food allergens, such as peanut ( Arachis hypogaea ) allergen Ara h 5, and pollen allergens, such as birch allergen Bet v 2. Patients with pollen allergy can also cross-react to peanut. Structural characterization of allergens will allow a better understanding of the allergenicity of food allergens and their cross-reactivities. The three-dimensional structures of most known food allergens remain to be elucidated. Here, we report the first crystallographic study of a food allergen in the profilin family. The structure of peanut allergen Ara h 5 was determined, and the resolution of the final refined structure was 1.1 Å. Structure alignment revealed that Ara h 5 is more similar to Bet v 2 than to Hev b 8, although sequence alignment suggested that Ara h 5 is more closely related to Hev b 8 than to Bet v 2, indicating that homology-model-based prediction of immunoglobulin E epitopes needs to be interpreted with caution.

PubMed: 23350842
DOI: 10.1021/jf303861p

実験手法

X-RAY DIFFRACTION (1.1 Å)