4EQ0

Crystal Structure of inactive single chain variant of HIV-1 Protease in Complex with the substrate p2-NC

4EQ0 の概要

• エントリーDOI: 10.2210/pdb4eq0/pdb
• 関連するPDBエントリー: 4EP2 4EP3 4EPJ 4EQJ
• 分子名称: protease, tethered dimer, substrate p2-NC, BETA-MERCAPTOETHANOL, ... (8 entities in total)
• 機能のキーワード: hiv-1 protease, specificity design, drug design, protease inhibitors, aids, aspartyl protease, hydrolase, hydrolase-hydrolase substrate complex, hydrolase/hydrolase substrate
• 由来する生物種: HIV-1 M:B_ARV2/SF2 (HIV-1); 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369; Host cytoplasm . Host nucleus . Matrix protein p17: Virion . Virion : Q9YP46
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 23771.99

構造登録者

Schiffer, C.A.,Mittal, S. (登録日: 2012-04-17, 公開日: 2012-06-06, 最終更新日: 2024-02-28)

• 主引用文献: Alvizo, O.,Mittal, S.,Mayo, S.L.,Schiffer, C.A.; Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease.; Protein Sci., 21:1029-1041, 2012; PubMed: 22549928; DOI: 10.1002/pro.2086

実験手法

X-RAY DIFFRACTION (1.7 Å)