4EOX

X-ray Structure of Polypeptide Deformylase Bound to a Acylprolinamide inhibitor

4EOX の概要

• エントリーDOI: 10.2210/pdb4eox/pdb
• 分子名称: Peptide deformylase, NICKEL (II) ION, N-benzoyl-1-[(2R)-3-cyclopentyl-2-{[formyl(hydroxy)amino]methyl}propanoyl]-L-prolinamide, ... (4 entities in total)
• 機能のキーワード: alpha-beta, peptide deformylase metal ion binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Streptococcus pneumoniae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23195.22

構造登録者

Ward, P.,Campobasso, N. (登録日: 2012-04-16, 公開日: 2012-05-30, 最終更新日: 2024-02-28)

主引用文献

Axten, J.M.,Medina, J.R.,Blackledge, C.W.,Duquenne, C.,Grant, S.W.,Bobko, M.A.,Peng, T.,Miller, W.H.,Pinckney, T.,Gallagher, T.F.,Kulkarni, S.,Lewandowski, T.,Van Aller, G.S.,Zonis, R.,Ward, P.,Campobasso, N.
Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity.
Bioorg.Med.Chem.Lett., 22:4028-4032, 2012

PubMed Abstract: A new class of PDF inhibitor with potent, broad spectrum antibacterial activity is described. Optimization of blood stability and potency provided compounds with improved pharmacokinetics that were suitable for in vivo experiments. Compound 5c, which has robust antibacterial activity, demonstrated efficacy in two respiratory tract infection models.

PubMed: 22579486
DOI: 10.1016/j.bmcl.2012.04.086

実験手法

X-RAY DIFFRACTION (1.783 Å)