4EN8

Crystal structure of HA70 (HA3) subcomponent of Clostridium botulinum type C progenitor toxin in complex with alpha 2-6-sialyllactose

Summary for 4EN8

• Entry DOI: 10.2210/pdb4en8/pdb
• Related: 2ZOE 2ZS6 4EN6 4EN7 4EN9
• Related PRD ID: PRD_900066
• Descriptor: Hemagglutinin components HA-22/23/53, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, (4R)-2-METHYLPENTANE-2,4-DIOL, ... (5 entities in total)
• Functional Keywords: carbohydrate/sugar binding, sugar binding protein
• Biological source: Clostridium botulinum; More
• Total number of polymer chains: 2
• Total formula weight: 74608.81

Authors

Yamashita, S.,Yoshida, H.,Tonozuka, T.,Nishikawa, A.,Kamitori, S. (deposition date: 2012-04-12, release date: 2012-06-06, Last modification date: 2023-11-08)

• Primary citation: Yamashita, S.,Yoshida, H.,Uchiyama, N.,Nakakita, Y.,Nakakita, S.,Tonozuka, T.,Oguma, K.,Nishikawa, A.,Kamitori, S.; Carbohydrate recognition mechanism of HA70 from Clostridium botulinum deduced from X-ray structures in complexes with sialylated oligosaccharides; Febs Lett., 586:2404-2410, 2012; PubMed: 22684008; DOI: 10.1016/j.febslet.2012.05.055

Experimental method

X-RAY DIFFRACTION (2.6 Å)