4EKX

Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18

Summary for 4EKX

Related4EEE
Descriptor14L protein, Interleukin-18 (3 entities in total)
Functional Keywordsbinding protein, beta trefoil, immunoglobulin fold, yldv, yaba, yatapoxvirus, 14l, cytokine signaling, cytokine-viral protein complex, cytokine/viral protein
Biological sourceYaba-like disease virus (YLDV)
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Cellular locationSecreted Q14116
Total number of polymer chains4
Total molecular weight63384.26
Authors
Krumm, B.E.,Xiang, Y.,Deng, J. (deposition date: 2012-04-10, release date: 2012-09-26, Last modification date: 2017-11-15)
Primary citation
Krumm, B.,Meng, X.,Wang, Z.,Xiang, Y.,Deng, J.
A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein.
Plos Pathog., 8:e1002876-e1002876, 2012
PubMed: 22927815 (PDB entries with the same primary citation)
DOI: 10.1371/journal.ppat.1002876
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.75 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2304007.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report