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4EHR

Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide

Summary for 4EHR
Entry DOI10.2210/pdb4ehr/pdb
DescriptorBcl-2-like protein 1, 4-[5-butyl-3-(hydroxymethyl)-1-phenyl-1H-pyrazol-4-yl]-3-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}benzamide, IMIDAZOLE, ... (4 entities in total)
Functional Keywordsapoptosis, programmed cell death, bcl-2 family
Biological sourceHomo sapiens (human)
Cellular locationMitochondrion membrane; Single-pass membrane protein: Q07817
Total number of polymer chains1
Total formula weight20337.49
Authors
Primary citationSchroeder, G.M.,Wei, D.,Banfi, P.,Cai, Z.W.,Lippy, J.,Menichincheri, M.,Modugno, M.,Naglich, J.,Penhallow, B.,Perez, H.L.,Sack, J.,Schmidt, R.J.,Tebben, A.,Yan, C.,Zhang, L.,Galvani, A.,Lombardo, L.J.,Borzilleri, R.M.
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists.
Bioorg.Med.Chem.Lett., 22:3951-3956, 2012
Cited by
PubMed: 22608393
DOI: 10.1016/j.bmcl.2012.04.106
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.09 Å)
Structure validation

217705

數據於2024-03-27公開中

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