4EHM

RabGGTase in complex with covalently bound Psoromic acid

Summary for 4EHM

Entry DOI	10.2210/pdb4ehm/pdb
Descriptor	Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, 4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepine-6-carboxylic acid, ... (6 entities in total)
Functional Keywords	prenylation, inhibition, psoromic acid, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	2
Total formula weight	75528.20
Authors	Guo, Z.,Deraeve, C.,Bon, R.S.,Alexandrov, K.,Waldmann, H.,Wu, Y.W.,Goody, R.S.,Blankenfeldt, W. (deposition date: 2012-04-02, release date: 2012-05-30, Last modification date: 2017-08-09)
Primary citation	Deraeve, C.,Guo, Z.,Bon, R.S.,Blankenfeldt, W.,Dilucrezia, R.,Wolf, A.,Menninger, S.,Stigter, E.A.,Wetzel, S.,Choidas, A.,Alexandrov, K.,Waldmann, H.,Goody, R.S.,Wu, Y.W. Psoromic Acid is a Selective and Covalent Rab-Prenylation Inhibitor Targeting Autoinhibited RabGGTase J.Am.Chem.Soc., 134:7384-7391, 2012 Cited by PubMed: 22480322 DOI: 10.1021/ja211305j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation