4EHM

RabGGTase in complex with covalently bound Psoromic acid

4EHM の概要

• エントリーDOI: 10.2210/pdb4ehm/pdb
• 分子名称: Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, 4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepine-6-carboxylic acid, ... (6 entities in total)
• 機能のキーワード: prenylation, inhibition, psoromic acid, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75528.20

構造登録者

Guo, Z.,Deraeve, C.,Bon, R.S.,Alexandrov, K.,Waldmann, H.,Wu, Y.W.,Goody, R.S.,Blankenfeldt, W. (登録日: 2012-04-02, 公開日: 2012-05-30, 最終更新日: 2017-08-09)

• 主引用文献: Deraeve, C.,Guo, Z.,Bon, R.S.,Blankenfeldt, W.,Dilucrezia, R.,Wolf, A.,Menninger, S.,Stigter, E.A.,Wetzel, S.,Choidas, A.,Alexandrov, K.,Waldmann, H.,Goody, R.S.,Wu, Y.W.; Psoromic Acid is a Selective and Covalent Rab-Prenylation Inhibitor Targeting Autoinhibited RabGGTase; J.Am.Chem.Soc., 134:7384-7391, 2012; PubMed: 22480322; DOI: 10.1021/ja211305j

実験手法

X-RAY DIFFRACTION (2.2 Å)