4EHG

B-Raf Kinase Domain in Complex with an Aminopyridimine-based Inhibitor

4EHG の概要

• エントリーDOI: 10.2210/pdb4ehg/pdb
• 関連するPDBエントリー: 4EHE
• 分子名称: Serine/threonine-protein kinase B-raf, N-{2,4-difluoro-3-[({6-[(2-hydroxyethyl)amino]pyrimidin-4-yl}carbamoyl)amino]phenyl}propane-1-sulfonamide (2 entities in total)
• 機能のキーワード: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus (By similarity): P15056
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71356.09

構造登録者

Voegtli, W.C. (登録日: 2012-04-02, 公開日: 2013-04-24, 最終更新日: 2024-02-28)

• 主引用文献: Mathieu, S.,Gradl, S.N.,Ren, L.,Wen, Z.,Aliagas, I.,Gunzner-Toste, J.,Lee, W.,Pulk, R.,Zhao, G.,Alicke, B.,Boggs, J.W.,Buckmelter, A.J.,Choo, E.F.,Dinkel, V.,Gloor, S.L.,Gould, S.E.,Hansen, J.D.,Hastings, G.,Hatzivassiliou, G.,Laird, E.R.,Moreno, D.,Ran, Y.,Voegtli, W.C.,Wenglowsky, S.,Grina, J.,Rudolph, J.; Potent and selective aminopyrimidine-based B-raf inhibitors with favorable physicochemical and pharmacokinetic properties.; J.Med.Chem., 55:2869-2881, 2012; PubMed: 22335519; DOI: 10.1021/jm300016v

実験手法

X-RAY DIFFRACTION (3.5 Å)