4EF8

Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with Phenyl isothiocyanate

4EF8 の概要

• エントリーDOI: 10.2210/pdb4ef8/pdb
• 関連するPDBエントリー: 4EF9
• 分子名称: Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, N-phenylthioformamide, ... (6 entities in total)
• 機能のキーワード: leishmania major, dihydroorotate dehydrogenase, phenyl isothiocyanate, pyrd, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Leishmania major
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78066.65

構造登録者

Pinheiro, M.P.,Emery, F.S.,Nonato, M.C. (登録日: 2012-03-29, 公開日: 2012-12-12, 最終更新日: 2023-09-13)

• 主引用文献: Pinheiro, M.P.,Emery, F.S.,Nonato, M.C.; Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase.; Curr.Pharm.Des., 19:2615-2627, 2013; PubMed: 23116399

実験手法

X-RAY DIFFRACTION (1.56 Å)