4EBL

BlaC E166A Faropenem Acyl-Intermediate Complex

Summary for 4EBL

• Entry DOI: 10.2210/pdb4ebl/pdb
• Related: 3VFF 3VFH 4EBI 4EBM 4EBN 4EBO 4EBP
• Descriptor: Beta-lactamase, PHOSPHATE ION, (2R,5R)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-5-[(2R)-tetrahydrofuran-2-yl]-2,5-dihydro-1,3-thiazole-4-carboxylic acid, ... (4 entities in total)
• Functional Keywords: ambler class a beta-lactamase, beta-lactamase, serine hydrolase, esterase, hydrolase-antibiotic complex, structural genomics, tb structural genomics consortium, tbsgc, hydrolase/antibiotic
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 4
• Total formula weight: 114193.19

Authors

Mire, J.A.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2012-03-23, release date: 2013-04-03, Last modification date: 2017-02-08)

• Primary citation: Mire, J.A.,Pai, P.,Siddiqi, N.,Russell, D.H.,Rubin, E.J.,Sacchettini, J.C.; Faropenem is Effective Against Mycobacterium tuberculosis in vitro and in vivo; To be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)