4EB4

Crystal structure of mouse thymidylate synthase in ternary complex with dUMP and Tomudex

4EB4 の概要

• エントリーDOI: 10.2210/pdb4eb4/pdb
• 分子名称: Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, ... (8 entities in total)
• 機能のキーワード: ternary complex, methyltransferase, nucleotide biosynthesis, transferase
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Nucleus : P07607
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 144437.23

構造登録者

Dowiercial, A.,Jarmula, A.,Rypniewski, W.R.,Wilk, P.,Rode, W. (登録日: 2012-03-23, 公開日: 2012-05-02, 最終更新日: 2024-02-28)

• 主引用文献: Dowiercial, A.,Wilk, P.,Rypniewski, W.,Rode, W.,Jarmula, A.; Crystal structure of mouse thymidylate synthase in tertiary complex with dUMP and raltitrexed reveals N-terminus architecture and two different active site conformations.; Biomed Res Int, 2014:945803-, 2014; PubMed: 24995339; DOI: 10.1155/2014/945803

実験手法

X-RAY DIFFRACTION (1.74 Å)