4EB1

Hyperstable in-frame insertion variant of antithrombin

Summary for 4EB1

• Entry DOI: 10.2210/pdb4eb1/pdb
• Related: 1E04
• Descriptor: Antithrombin-III, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: serpin, hydrolase inhibitor, blood clotting
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P01008 P01008
• Total number of polymer chains: 2
• Total formula weight: 100319.26

Authors

Martinez-Martinez, I.,Johnson, D.J.D.,Yamasaki, M.,Corral, J.,Huntington, J.A. (deposition date: 2012-03-23, release date: 2012-07-18, Last modification date: 2023-09-13)

• Primary citation: Martinez-Martinez, I.,Johnson, D.J.,Yamasaki, M.,Navarro-Fernandez, J.,Ordonez, A.,Vicente, V.,Huntington, J.A.,Corral, J.; Type II antithrombin deficiency caused by a large in-frame insertion: structural, functional and pathological relevance.; J.Thromb.Haemost., 10:1859-1866, 2012; PubMed: 22758787; DOI: 10.1111/j.1538-7836.2012.04839.x

Experimental method

X-RAY DIFFRACTION (2.8 Å)