Summary for 5Z2Q
| Entry DOI | 10.2210/pdb5z2q/pdb |
| Descriptor | Transcription cofactor vestigial-like protein 1, Transcriptional enhancer factor TEF-3, PHOSPHATE ION, ... (6 entities in total) |
| Functional Keywords | tead, transcription factor, co-regulator, vgll1, vestigial, transcription |
| Biological source | Mus musculus (Mouse) More |
| Cellular location | Nucleus : Q99NC0 Q99NC0 Q62296 Q62296 |
| Total number of polymer chains | 4 |
| Total formula weight | 64660.74 |
| Authors | Pobbati, A.V.,Song, H. (deposition date: 2018-01-03, release date: 2018-01-31, Last modification date: 2023-11-22) |
| Primary citation | Pobbati, A.V.,Chan, S.W.,Lee, I.,Song, H.,Hong, W. Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes. Structure, 20:1135-1140, 2012 Cited by PubMed Abstract: The structure of the complex between the transcription cofactor Vgll1 and the transcription factor TEAD4, the mammalian equivalent of the Drosophila Vestigial and Scalloped, respectively, is determined in this study. Remarkably, Vgll1 interacts with TEAD in a manner similar to the transcription coactivators, as well as oncogenes YAP and TAZ, despite having a varied primary sequence. Vgll1-TEAD complex upregulates the expression of IGFBP-5, a proliferation-promoting gene, and facilitates anchorage-independent cell proliferation. The YAP/TAZ-TEAD complex also upregulates several other proliferation-promoting genes and also promotes anchorage-independent cell proliferation. Given its structural and functional similarity to YAP/TAZ, Vgll1 has the potential to promote cancer progression. PubMed: 22632831DOI: 10.1016/j.str.2012.04.004 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.74 Å) |
Structure validation
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