4EAR
Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with DADMe-ImmG and phosphate
4EAR の概要
エントリーDOI | 10.2210/pdb4ear/pdb |
分子名称 | Purine nucleoside phosphorylase, 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, ... (4 entities in total) |
機能のキーワード | pnp, immucillin, purine nucleoside phosphorylase, nucleoside binding, purine base binding, purine-nucleoside phosphorylase activity, drug binding, transferase activity, transferring glycosyl groups, phosphate ion binding, cytosol, 6-fluoro-l-tryptophan, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm, cytoskeleton (By similarity): P00491 |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 109558.15 |
構造登録者 | Haapalainen, A.M.,Ho, M.C.,Suarez, J.J.,Almo, S.C.,Schramm, V.L. (登録日: 2012-03-22, 公開日: 2013-02-06, 最終更新日: 2013-03-13) |
主引用文献 | Suarez, J.,Haapalainen, A.M.,Cahill, S.M.,Ho, M.C.,Yan, F.,Almo, S.C.,Schramm, V.L. Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography. Chem.Biol., 20:212-222, 2013 Cited by PubMed: 23438750DOI: 10.1016/j.chembiol.2013.01.009 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.7 Å) |
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