4E5D

2.2A resolution structure of a firefly luciferase-benzothiazole inhibitor complex

4E5D の概要

• エントリーDOI: 10.2210/pdb4e5d/pdb
• 分子名称: Luciferin 4-monooxygenase, 2-(2-fluorophenyl)-6-methoxy-1,3-benzothiazole (3 entities in total)
• 機能のキーワード: oxidoreductase, monooxygenase, photoprotein, luminescence, profiling, pubchem, luciferase, quantitative high-throughput screening, qhts, firefly luciferase, reporter-gene assays, adenylate forming enzymes, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Photinus pyralis (North American firefly)
• 細胞内の位置: Peroxisome : P08659
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61078.25

構造登録者

Lovell, S.,Battaile, K.P.,Throne, N.,Shen, M.,Auld, D.S.,Inglese, J. (登録日: 2012-03-14, 公開日: 2012-09-05, 最終更新日: 2023-09-13)

• 主引用文献: Thorne, N.,Shen, M.,Lea, W.A.,Simeonov, A.,Lovell, S.,Auld, D.S.,Inglese, J.; Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter.; Chem.Biol., 19:1060-1072, 2012; PubMed: 22921073; DOI: 10.1016/j.chembiol.2012.07.015

実験手法

X-RAY DIFFRACTION (2.201 Å)