4E3O
Crystal structure of AmpC beta-lactamase in complex with a small chloromethyl sulfonamide boronic acid inhibitor
Summary for 4E3O
| Entry DOI | 10.2210/pdb4e3o/pdb |
| Related | 4E3I 4E3J 4E3K 4E3L 4E3M 4E3N |
| Descriptor | Beta-lactamase, ({[(chloromethyl)sulfonyl]amino}methyl)boronic acid, PHOSPHATE ION, ... (4 entities in total) |
| Functional Keywords | ampc beta-lactamase, class c, cephalosporinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Escherichia coli |
| Cellular location | Periplasm: P00811 |
| Total number of polymer chains | 2 |
| Total formula weight | 79930.55 |
| Authors | Eidam, O.,Shoichet, B.K. (deposition date: 2012-03-09, release date: 2012-09-26, Last modification date: 2023-09-13) |
| Primary citation | Eidam, O.,Romagnoli, C.,Dalmasso, G.,Barelier, S.,Caselli, E.,Bonnet, R.,Shoichet, B.K.,Prati, F. Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo. Proc.Natl.Acad.Sci.USA, 109:17448-17453, 2012 Cited by PubMed: 23043117DOI: 10.1073/pnas.1208337109 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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