4E02

Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/(S)-2-chloro-3-phenylpropanoic acid complex with AMPPNP

Summary for 4E02

• Entry DOI: 10.2210/pdb4e02/pdb
• Related: 3TZ0 3TZ2 3TZ4 3TZ5 4DZY 4E01
• Descriptor: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, POTASSIUM ION, ... (6 entities in total)
• Functional Keywords: ghkl protein kinase, allosteric kinase inhibitor, branched-chain alpha-ketoacid, branched-chain amino acids, maple syrup urine disease, diabetes and obesity, bergerat nucleotide-binding fold, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Rattus norvegicus (brown rat,rat,rats)
• Cellular location: Mitochondrion matrix: Q00972
• Total number of polymer chains: 1
• Total formula weight: 48128.47

Authors

Tso, S.C.,Chuang, J.L.,Gui, W.J.,Wynn, R.M.,Li, J.,Chuang, D.T. (deposition date: 2012-03-02, release date: 2013-03-13, Last modification date: 2023-09-13)

• Primary citation: Tso, S.C.,Chuang, J.L.,Gui, W.J.,Wynn, R.M.,Li, J.,Chuang, D.T.; Structures of branched-chain alpha-ketoacid dehydrogenase kinase-inhibitor complexes; To be Published,

Experimental method

X-RAY DIFFRACTION (2.1547 Å)