4DYM

Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135

Summary for 4DYM

• Entry DOI: 10.2210/pdb4dym/pdb
• Related: 3MTF 3OOM
• Descriptor: Activin receptor type-1, SULFATE ION, 1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE, ... (5 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: Q04771
• Total number of polymer chains: 1
• Total formula weight: 35398.49

Authors

Chaikuad, A.,Sanvitale, C.,Cooper, C.,Canning, P.,Mahajan, P.,Daga, N.,Petrie, K.,Alfano, I.,Gileadi, O.,Fedorov, O.,Krojer, T.,Filippakopoulos, P.,Muniz, J.R.C.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2012-02-29, release date: 2012-03-21, Last modification date: 2023-09-13)

• Primary citation: Chaikuad, A.,Sanvitale, C.,Cooper, C.,Canning, P.,Mahajan, P.,Daga, N.,Petrie, K.,Alfano, I.,Gileadi, O.,Fedorov, O.,Krojer, T.,Filippakopoulos, P.,Muniz, J.R.C.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC); Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135; To be Published,

Experimental method

X-RAY DIFFRACTION (2.42 Å)