4DYM
Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135
Summary for 4DYM
Entry DOI | 10.2210/pdb4dym/pdb |
Related | 3MTF 3OOM |
Descriptor | Activin receptor type-1, SULFATE ION, 1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE, ... (5 entities in total) |
Functional Keywords | structural genomics, structural genomics consortium, sgc, protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: Q04771 |
Total number of polymer chains | 1 |
Total formula weight | 35398.49 |
Authors | Chaikuad, A.,Sanvitale, C.,Cooper, C.,Canning, P.,Mahajan, P.,Daga, N.,Petrie, K.,Alfano, I.,Gileadi, O.,Fedorov, O.,Krojer, T.,Filippakopoulos, P.,Muniz, J.R.C.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2012-02-29, release date: 2012-03-21, Last modification date: 2023-09-13) |
Primary citation | Chaikuad, A.,Sanvitale, C.,Cooper, C.,Canning, P.,Mahajan, P.,Daga, N.,Petrie, K.,Alfano, I.,Gileadi, O.,Fedorov, O.,Krojer, T.,Filippakopoulos, P.,Muniz, J.R.C.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135 To be Published, |
Experimental method | X-RAY DIFFRACTION (2.42 Å) |
Structure validation
Download full validation report