4DY0

Crystal structure of native protease nexin-1 with heparin

Summary for 4DY0

• Entry DOI: 10.2210/pdb4dy0/pdb
• Descriptor: Glia-derived nexin, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, SULFATE ION, ... (5 entities in total)
• Functional Keywords: serpin, protease inhibitor, thrombin, cell surface, hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 84994.90

Authors

Huntington, J.A.,Li, W. (deposition date: 2012-02-28, release date: 2012-08-15, Last modification date: 2024-03-13)

• Primary citation: Li, W.,Huntington, J.A.; Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.; Blood, 120:459-467, 2012; PubMed: 22618708; DOI: 10.1182/blood-2012-03-415869

Experimental method

X-RAY DIFFRACTION (2.35 Å)