4DX7

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

4DX7 の概要

• エントリーDOI: 10.2210/pdb4dx7/pdb
• 関連するPDBエントリー: 4DX5 4DX6
• 分子名称: Acriflavine resistance protein B, DARPIN, DODECYL-BETA-D-MALTOSIDE, ... (10 entities in total)
• 機能のキーワード: darpin, multidrug efflux protein, membrane protein, transport protein
• 由来する生物種: Escherichia coli; 詳細
• 細胞内の位置: Cell inner membrane; Multi-pass membrane protein: P31224
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 388258.58

構造登録者

Eicher, T.,Cha, H.,Seeger, M.A.,Brandstaetter, L.,El-Delik, J.,Bohnert, J.A.,Kern, W.V.,Verrey, F.,Gruetter, M.G.,Diederichs, K.,Pos, K.M. (登録日: 2012-02-27, 公開日: 2012-05-02, 最終更新日: 2024-02-28)

• 主引用文献: Eicher, T.,Cha, H.J.,Seeger, M.A.,Brandstatter, L.,El-Delik, J.,Bohnert, J.A.,Kern, W.V.,Verrey, F.,Grutter, M.G.,Diederichs, K.,Pos, K.M.; Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.; Proc.Natl.Acad.Sci.USA, 109:5687-5692, 2012; PubMed: 22451937; DOI: 10.1073/pnas.1114944109

実験手法

X-RAY DIFFRACTION (2.253 Å)