4DWG

Crystal structure of Trypanosome cruzi farnesyl diphosphate synthase in complex with [2-(n-heptylamino)ethane-1,1-diyl]bisphosphonic acid and Mg2+

4DWG の概要

• エントリーDOI: 10.2210/pdb4dwg/pdb
• 関連するPDBエントリー: 1YHK 1YHL 1YHM 3IBA 3ICK 3ICM 3ICN 3ICZ 4DWB 4DXJ
• 分子名称: Farnesyl pyrophosphate synthase, MAGNESIUM ION, [2-(heptylamino)ethane-1,1-diyl]bis(phosphonic acid), ... (8 entities in total)
• 機能のキーワード: geranyl transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Trypanosoma cruzi
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42100.80

構造登録者

Aripirala, S.,Amzel, L.M.,Gabelli, S.B. (登録日: 2012-02-24, 公開日: 2013-01-16, 最終更新日: 2023-09-13)

• 主引用文献: Aripirala, S.,Szajnman, S.H.,Jakoncic, J.,Rodriguez, J.B.,Docampo, R.,Gabelli, S.B.,Amzel, L.M.; Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase.; J.Med.Chem., 55:6445-6454, 2012; PubMed: 22715997; DOI: 10.1021/jm300425y

実験手法

X-RAY DIFFRACTION (2.01 Å)