4DTK

Novel and selective pan-PIM kinase inhibitor

Summary for 4DTK

Entry DOI	10.2210/pdb4dtk/pdb
Descriptor	Serine/threonine-protein kinase pim-1, 1,2-ETHANEDIOL, (5Z)-5-{2-[(3R)-3-aminopiperidin-1-yl]-3-(propan-2-yloxy)benzylidene}-1,3-thiazolidine-2,4-dione, ... (5 entities in total)
Functional Keywords	pim1, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	32893.26
Authors	Ferguson, A.D. (deposition date: 2012-02-21, release date: 2012-07-11, Last modification date: 2024-02-28)
Primary citation	Dakin, L.A.,Block, M.H.,Chen, H.,Code, E.,Dowling, J.E.,Feng, X.,Ferguson, A.D.,Green, I.,Hird, A.W.,Howard, T.,Keeton, E.K.,Lamb, M.L.,Lyne, P.D.,Pollard, H.,Read, J.,Wu, A.J.,Zhang, T.,Zheng, X. Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. Bioorg.Med.Chem.Lett., 22:4599-4604, 2012 Cited by PubMed Abstract: Novel substituted benzylidene-1,3-thiazolidine-2,4-diones (TZDs) have been identified as potent and highly selective inhibitors of the PIM kinases. The synthesis and SAR of these compounds are described, along with X-ray crystallographic, anti-proliferative, and selectivity data. PubMed: 22727640 DOI: 10.1016/j.bmcl.2012.05.098 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation