4DTK

Novel and selective pan-PIM kinase inhibitor

4DTK の概要

• エントリーDOI: 10.2210/pdb4dtk/pdb
• 分子名称: Serine/threonine-protein kinase pim-1, 1,2-ETHANEDIOL, (5Z)-5-{2-[(3R)-3-aminopiperidin-1-yl]-3-(propan-2-yloxy)benzylidene}-1,3-thiazolidine-2,4-dione, ... (5 entities in total)
• 機能のキーワード: pim1, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32893.26

構造登録者

Ferguson, A.D. (登録日: 2012-02-21, 公開日: 2012-07-11, 最終更新日: 2024-02-28)

• 主引用文献: Dakin, L.A.,Block, M.H.,Chen, H.,Code, E.,Dowling, J.E.,Feng, X.,Ferguson, A.D.,Green, I.,Hird, A.W.,Howard, T.,Keeton, E.K.,Lamb, M.L.,Lyne, P.D.,Pollard, H.,Read, J.,Wu, A.J.,Zhang, T.,Zheng, X.; Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases.; Bioorg.Med.Chem.Lett., 22:4599-4604, 2012; PubMed: 22727640; DOI: 10.1016/j.bmcl.2012.05.098

実験手法

X-RAY DIFFRACTION (1.86 Å)