4DST
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
Summary for 4DST
Entry DOI | 10.2210/pdb4dst/pdb |
Related | 4DSN 4DSO 4DSU |
Descriptor | GTPase KRas, isoform 2B, 2-(4,6-dichloro-2-methyl-1H-indol-3-yl)ethanamine, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... (9 entities in total) |
Functional Keywords | small g-protein, signaling, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Lipid-anchor; Cytoplasmic side: P01116 |
Total number of polymer chains | 1 |
Total formula weight | 22634.86 |
Authors | Oh, A.,Maurer, T.,Garrenton, L.S.,Pitts, K.,Anderson, D.J.,Skelton, N.J.,Fauber, B.P.,Pan, B.,Malek, S.,Stokoe, D.,Ludlam, M.,Bowman, K.K.,Wu, J.,Giannetti, A.M.,Starovasnik, M.A.,Mellman, I.,Jackson, P.K.,Ruldolph, J.,Fang, G.,Wang, W. (deposition date: 2012-02-19, release date: 2012-04-04, Last modification date: 2024-02-28) |
Primary citation | Maurer, T.,Garrenton, L.S.,Oh, A.,Pitts, K.,Anderson, D.J.,Skelton, N.J.,Fauber, B.P.,Pan, B.,Malek, S.,Stokoe, D.,Ludlam, M.J.,Bowman, K.K.,Wu, J.,Giannetti, A.M.,Starovasnik, M.A.,Mellman, I.,Jackson, P.K.,Rudolph, J.,Wang, W.,Fang, G. Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc.Natl.Acad.Sci.USA, 109:5299-5304, 2012 Cited by PubMed: 22431598DOI: 10.1073/pnas.1116510109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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