4DS6

Crystal structure of a group II intron in the pre-catalytic state

4DS6 の概要

• エントリーDOI: 10.2210/pdb4ds6/pdb
• 分子名称: Mutant Group IIC Intron, MAGNESIUM ION (3 entities in total)
• 機能のキーワード: rna, ribonucleic acid, intron, group ii
• 由来する生物種: Oceanobacillus iheyensis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 137288.94

構造登録者

Chan, R.T.,Robart, A.R.,Rajashankar, K.R.,Pyle, A.M.,Toor, N. (登録日: 2012-02-17, 公開日: 2012-04-18, 最終更新日: 2023-09-13)

主引用文献

Chan, R.T.,Robart, A.R.,Rajashankar, K.R.,Pyle, A.M.,Toor, N.
Crystal structure of a group II intron in the pre-catalytic state.
Nat.Struct.Mol.Biol., 19:555-557, 2012

PubMed Abstract: Group II introns are self-splicing catalytic RNAs that are thought to be ancestral to the spliceosome. Here we report the 3.65-Å crystal structure of the group II intron from Oceanobacillus iheyensis in the pre-catalytic state. The structure reveals the conformation of the 5' splice site in the catalytic core and represents the first structure of an intron prior to the first step of splicing.

PubMed: 22484319
DOI: 10.1038/nsmb.2270

実験手法

X-RAY DIFFRACTION (3.644 Å)