4DRQ
Exploration of Pipecolate Sulfonamides as Binders of the FK506-Binding Proteins 51 and 52: Complex of FKBP51 with 2-(3-((R)-1-((S)-1-(3,5-dichlorophenylsulfonyl)piperidine-2-carbonyloxy)-3-(3,4-dimethoxy -phenyl)propyl)phenoxy)acetic acid
Summary for 4DRQ
Entry DOI | 10.2210/pdb4drq/pdb |
Related | 4DRK 4DRM 4DRN 4DRo 4DRp |
Descriptor | Peptidyl-prolyl cis-trans isomerase FKBP5, {3-[(1S)-1-[({(2S)-1-[(3,5-dichlorophenyl)sulfonyl]piperidin-2-yl}carbonyl)oxy]-3-(3,4-dimethoxyphenyl)propyl]phenoxy}acetic acid (3 entities in total) |
Functional Keywords | fk-506 binding domain, hsp90 cochaperone, immunophilin, peptidyl-prolyl isomerase, isomerase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q13451 |
Total number of polymer chains | 1 |
Total formula weight | 14692.64 |
Authors | Gopalakrishnan, R.,Kozany, C.,Wang, Y.,Hoogeland, B.,Bracher, A.,Hausch, F.,Schneider, S. (deposition date: 2012-02-17, release date: 2012-04-18, Last modification date: 2023-09-13) |
Primary citation | Gopalakrishnan, R.,Kozany, C.,Wang, Y.,Schneider, S.,Hoogeland, B.,Bracher, A.,Hausch, F. Exploration of Pipecolate Sulfonamides as Binders of the FK506-Binding Proteins 51 and 52. J.Med.Chem., 55:4123-4131, 2012 Cited by PubMed: 22455398DOI: 10.1021/jm201747c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1 Å) |
Structure validation
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