4DO4

Pharmacological chaperones for human alpha-N-acetylgalactosaminidase

4DO4 の概要

• エントリーDOI: 10.2210/pdb4do4/pdb
• 関連するPDBエントリー: 3H53 3H54 3H55 3IGU 4DO5 4DO6
• 分子名称: Alpha-N-acetylgalactosaminidase, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: pharmacological chaperone, (beta/alpha)8 barrel, glycosidase, carbohydrate-binding protein, glycoprotein, lysosome, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: P17050
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 96636.85

構造登録者

Clark, N.E.,Garman, S.C. (登録日: 2012-02-09, 公開日: 2012-10-10, 最終更新日: 2023-09-13)

• 主引用文献: Clark, N.E.,Metcalf, M.C.,Best, D.,Fleet, G.W.,Garman, S.C.; Pharmacological chaperones for human alpha-N-acetylgalactosaminidase; Proc.Natl.Acad.Sci.USA, 109:17400-17405, 2012; PubMed: 23045655; DOI: 10.1073/pnas.1203924109

実験手法

X-RAY DIFFRACTION (1.4 Å)