4DL1

Crystal Structure of human Myeloperoxidase with covalent thioxanthine analog

4DL1 の概要

• エントリーDOI: 10.2210/pdb4dl1/pdb
• 分子名称: Myeloperoxidase light chain, Myeloperoxidase heavy chain, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: oxidoreductase, heme-dependent peroxidase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 16
• 化学式量合計: 541355.54

構造登録者

Vajdos, F.,Varghese, A. (登録日: 2012-02-05, 公開日: 2012-03-21, 最終更新日: 2020-07-29)

• 主引用文献: Geoghegan, K.F.,Varghese, A.H.,Feng, X.,Bessire, A.J.,Conboy, J.J.,Ruggeri, R.B.,Ahn, K.,Spath, S.N.,Filippov, S.V.,Conrad, S.J.,Carpino, P.A.,Guimaraes, C.R.,Vajdos, F.F.; Deconstruction of activity-dependent covalent modification of heme in human neutrophil myeloperoxidase by multistage mass spectrometry (MS(4)).; Biochemistry, 51:2065-2077, 2012; PubMed: 22352991; DOI: 10.1021/bi201872j

実験手法

X-RAY DIFFRACTION (2 Å)