4DHL

Crystal structure of red kidney bean purple acid phosphatase in complex with Maybridge fragment MO07123

4DHL の概要

• エントリーDOI: 10.2210/pdb4dhl/pdb
• 分子名称: Purple acid phosphatase, 2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: catalytic c domain, n terminal domain, phosphatase, acid phosphatase, phosphoric monoester hydrolases, hydrolase, mo07123, maybridge, fragment, lysosome
• 由来する生物種: Phaseolus vulgaris (French bean,kidney bean,string bean)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 206786.41

構造登録者

Feder, D.,Clayton, D.J.,Hussein, W.M.,Schenk, G.,McGeary, R.,Guddat, L.W. (登録日: 2012-01-29, 公開日: 2012-12-12, 最終更新日: 2020-07-29)

• 主引用文献: Feder, D.,Hussein, W.M.,Clayton, D.J.,Kan, M.W.,Schenk, G.,McGeary, R.P.,Guddat, L.W.; Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics.; Chem.Biol.Drug Des., 80:665-674, 2012; PubMed: 22943065; DOI: 10.1111/cbdd.12001

実験手法

X-RAY DIFFRACTION (2.3 Å)