4DGP

The wild-type Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2)

Summary for 4DGP

Entry DOI	10.2210/pdb4dgp/pdb
Related	4DGX
Descriptor	Tyrosine-protein phosphatase non-receptor type 11 (2 entities in total)
Functional Keywords	hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q06124
Total number of polymer chains	1
Total formula weight	61761.64
Authors	Yu, Z.H.,Xu, J.,Walls, C.D.,Chen, L.,Zhang, S.,Wu, L.,Wang, L.N.,Liu, S.J.,Zhang, Z.Y. (deposition date: 2012-01-26, release date: 2013-03-06, Last modification date: 2024-02-28)
Primary citation	Yu, Z.H.,Xu, J.,Walls, C.D.,Chen, L.,Zhang, S.,Zhang, R.,Wu, L.,Wang, L.,Liu, S.,Zhang, Z.Y. Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations. J.Biol.Chem., 288:10472-10482, 2013 Cited by PubMed: 23457302 DOI: 10.1074/jbc.M113.450023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation