4DEN

Structural insightsinto potent, specific anti-HIV property of actinohivin; Crystal structure of actinohivin in complex with alpha(1-2) mannobiose moiety of high-mannose type glycan of gp120

Summary for 4DEN

• Entry DOI: 10.2210/pdb4den/pdb
• Related: 3A07
• Related PRD ID: PRD_900111
• Descriptor: Actinohivin, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose, POTASSIUM ION, ... (4 entities in total)
• Functional Keywords: anti-hiv lectin, molecular recognition, high-mannose type glycan, antiviral protein
• Biological source: Actinomycete
• Total number of polymer chains: 1
• Total formula weight: 13676.68

Authors

Hoque, M.M.,Suzuki, K.,Tsunoda, M.,Jiang, J.,Zhang, F.,Takahashi, A.,Naomi, O.,Zhang, X.,Sekiguchi, T.,Tanaka, H.,Omura, S.,Takenaka, A. (deposition date: 2012-01-20, release date: 2012-11-28, Last modification date: 2023-11-08)

• Primary citation: Hoque, M.M.,Suzuki, K.,Tsunoda, M.,Jiang, J.,Zhang, F.,Takahashi, A.,Ohbayashi, N.,Zhang, X.,Tanaka, H.,Omura, S.,Takenaka, A.; Structural insights into the specific anti-HIV property of actinohivin: structure of its complex with the alpha(1–2)mannobiose moiety of gp120; Acta Crystallogr.,Sect.D, 68:1671-1679, 2012; PubMed: 23151632; DOI: 10.1107/S0907444912040498

Experimental method

X-RAY DIFFRACTION (1.6 Å)