4DDK
Pantothenate synthetase in complex with 1,3-benzodioxole-5-carboxylic acid
Summary for 4DDK
Entry DOI | 10.2210/pdb4ddk/pdb |
Related | 4DDH 4DDM |
Descriptor | Pantothenate synthetase, 1,3-benzodioxole-5-carboxylic acid, GLYCEROL, ... (6 entities in total) |
Functional Keywords | fragment-based drug discovery, alpha beta/adenine nucleotide alpha hydrolase-like, pantoate and b-ala binding, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Mycobacterium tuberculosis |
Cellular location | Cytoplasm (Potential): P0A5R0 |
Total number of polymer chains | 2 |
Total formula weight | 64163.33 |
Authors | Silvestre, H.L. (deposition date: 2012-01-18, release date: 2013-02-13, Last modification date: 2023-09-13) |
Primary citation | Silvestre, H.L.,Blundell, T.L.,Abell, C.,Ciulli, A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proc.Natl.Acad.Sci.USA, 110:12984-12989, 2013 Cited by PubMed: 23872845DOI: 10.1073/pnas.1304045110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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