4DCK

Crystal structure of the C-terminus of voltage-gated sodium channel in complex with FGF13 and CaM

Summary for 4DCK

Entry DOI	10.2210/pdb4dck/pdb
Descriptor	Sodium channel protein type 5 subunit alpha, Calmodulin, Fibroblast growth factor 13, ... (5 entities in total)
Functional Keywords	iq-motif, ef-hand, voltage-gated sodium channel regulation, nav1.5 ctd binds to fgf13 and cam. cam binds to ca2+., transport protein-transport protein regulator-signaling protein complex, transport protein-signaling protein complex, transport protein/signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Multi-pass membrane protein: Q14524 Cytoplasm, cytoskeleton, spindle: P62158
Total number of polymer chains	3
Total formula weight	57904.94
Authors	Chung, B.C.,Wang, C.,Yan, H.,Pitt, G.S.,Lee, S.Y. (deposition date: 2012-01-17, release date: 2012-06-27, Last modification date: 2024-02-28)
Primary citation	Wang, C.,Chung, B.C.,Yan, H.,Lee, S.Y.,Pitt, G.S. Crystal Structure of the Ternary Complex of a NaV C-Terminal Domain, a Fibroblast Growth Factor Homologous Factor, and Calmodulin. Structure, 20:1167-1176, 2012 Cited by PubMed: 22705208 DOI: 10.1016/j.str.2012.05.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation