4DCK

Crystal structure of the C-terminus of voltage-gated sodium channel in complex with FGF13 and CaM

4DCK の概要

• エントリーDOI: 10.2210/pdb4dck/pdb
• 分子名称: Sodium channel protein type 5 subunit alpha, Calmodulin, Fibroblast growth factor 13, ... (5 entities in total)
• 機能のキーワード: iq-motif, ef-hand, voltage-gated sodium channel regulation, nav1.5 ctd binds to fgf13 and cam. cam binds to ca2+., transport protein-transport protein regulator-signaling protein complex, transport protein-signaling protein complex, transport protein/signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Multi-pass membrane protein: Q14524; Cytoplasm, cytoskeleton, spindle: P62158
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 57904.94

構造登録者

Chung, B.C.,Wang, C.,Yan, H.,Pitt, G.S.,Lee, S.Y. (登録日: 2012-01-17, 公開日: 2012-06-27, 最終更新日: 2024-02-28)

• 主引用文献: Wang, C.,Chung, B.C.,Yan, H.,Lee, S.Y.,Pitt, G.S.; Crystal Structure of the Ternary Complex of a NaV C-Terminal Domain, a Fibroblast Growth Factor Homologous Factor, and Calmodulin.; Structure, 20:1167-1176, 2012; PubMed: 22705208; DOI: 10.1016/j.str.2012.05.001

実験手法

X-RAY DIFFRACTION (2.2 Å)