4DAG

Structure of the Human Metapneumovirus Fusion Protein with Neutralizing Antibody Identifies a Pneumovirus Antigenic Site

4DAG の概要

• エントリーDOI: 10.2210/pdb4dag/pdb
• 分子名称: Fusion glycoprotein F0, Neutralizing Antibody DS7 heavy chain, Neutralizing Antibody DS7 light chain, ... (4 entities in total)
• 機能のキーワード: viral protein, mpv fusion protein, antibody, immune system, ds7 antibody structure, ds7, fab structure, vaccine, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human metapneumovirus; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 92414.73

構造登録者

Jardetzky, T.S.,Wen, X. (登録日: 2012-01-12, 公開日: 2012-02-29, 最終更新日: 2024-11-20)

主引用文献

Wen, X.,Krause, J.C.,Leser, G.P.,Cox, R.G.,Lamb, R.A.,Williams, J.V.,Crowe, J.E.,Jardetzky, T.S.
Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site.
Nat.Struct.Mol.Biol., 19:461-463, 2012

PubMed Abstract: Human metapneumovirus and respiratory syncytial virus cause lower respiratory tract infections. The virus fusion (F) glycoprotein promotes membrane fusion by refolding from a metastable pre-fusion to a stable post-fusion conformation. F is also a major target of the neutralizing antibody response. Here we show that a potently neutralizing anti-human metapneumovirus antibody (DS7) binds a structurally invariant domain of F, revealing a new epitope that could be targeted in vaccine development.

PubMed: 22388735
DOI: 10.1038/nsmb.2250

実験手法

X-RAY DIFFRACTION (3.3904 Å)