4DA3
Crystal structure of an intramolecular human telomeric DNA G-quadruplex 21-mer bound by the naphthalene diimide compound MM41.
Summary for 4DA3
Entry DOI | 10.2210/pdb4da3/pdb |
Related | 3SC8 3T5E 3UYH 4DAQ |
Descriptor | DNA (5'-D(*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*G)-3'), POTASSIUM ION, 4,9-bis{[3-(4-methylpiperazin-1-yl)propyl]amino}-2,7-bis[3-(morpholin-4-yl)propyl]benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetrone, ... (4 entities in total) |
Functional Keywords | intramolecular, ligand-complex, g-quadruplex, telomere, dna |
Biological source | Synthetic DNA |
Total number of polymer chains | 1 |
Total formula weight | 7618.64 |
Authors | Collie, G.W.,Neidle, S. (deposition date: 2012-01-12, release date: 2013-01-30, Last modification date: 2023-09-13) |
Primary citation | Micco, M.,Collie, G.W.,Dale, A.G.,Ohnmacht, S.A.,Pazitna, I.,Gunaratnam, M.,Reszka, A.P.,Neidle, S. Structure-based design and evaluation of naphthalene diimide g-quadruplex ligands as telomere targeting agents in pancreatic cancer cells. J.Med.Chem., 56:2959-2974, 2013 Cited by PubMed: 23514618DOI: 10.1021/jm301899y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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