4D8Z
Crystal structure of B. anthracis DHPS with compound 24
Summary for 4D8Z
Entry DOI | 10.2210/pdb4d8z/pdb |
Related | 1TWS 4D8A 4D9P 4DAF 4DAI 4DB7 |
Descriptor | Dihydropteroate Synthase, SULFATE ION, (3R)-3-(7-amino-4,5-dioxo-1,4,5,6-tetrahydropyrimido[4,5-c]pyridazin-3-yl)butanoic acid, ... (4 entities in total) |
Functional Keywords | tim barrel, dhps, dhps inhibitors, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Bacillus anthracis (anthrax) |
Total number of polymer chains | 2 |
Total formula weight | 67162.48 |
Authors | Hammoudeh, D.,Lee, R.E.,White, S.W. (deposition date: 2012-01-11, release date: 2012-03-28, Last modification date: 2023-09-13) |
Primary citation | Zhao, Y.,Hammoudeh, D.,Yun, M.K.,Qi, J.,White, S.W.,Lee, R.E. Structure-Based Design of Novel Pyrimido[4,5-c]pyridazine Derivatives as Dihydropteroate Synthase Inhibitors with Increased Affinity. Chemmedchem, 7:861-870, 2012 Cited by PubMed: 22416048DOI: 10.1002/cmdc.201200049 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.198 Å) |
Structure validation
Download full validation report