4D72

Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the type 2 blood group A-tetrasaccharide (E558A L19 mutant)

4D72 の概要

• エントリーDOI: 10.2210/pdb4d72/pdb
• 関連するPDBエントリー: 4D71
• 関連するBIRD辞書のPRD_ID: PRD_900036
• 分子名称: GLYCOSIDE HYDROLASE, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-alpha-D-galactopyranose, ... (5 entities in total)
• 機能のキーワード: hydrolase, blood group antigen
• 由来する生物種: STREPTOCOCCUS PNEUMONIAE
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 69555.99

構造登録者

Kwan, D.H.,Constantinescu, I.,Chapanian, R.,Higgins, M.A.,Samain, E.,Boraston, A.B.,Kizhakkedathu, J.N.,Withers, S.G. (登録日: 2014-11-19, 公開日: 2015-01-21, 最終更新日: 2023-12-20)

• 主引用文献: Kwan, D.H.,Constantinescu, I.,Chapanian, R.,Higgins, M.A.,Koetzler, M.,Samain, E.,Boraston, A.B.,Kizhakkedathu, J.N.,Withers, S.G.; Towards Efficient Enzymes for the Generation of Universal Blood Through Structure-Guided Directed Evolution.; J.Am.Chem.Soc., 137:5695-, 2015; PubMed: 25870881; DOI: 10.1021/JA5116088

実験手法

X-RAY DIFFRACTION (2.11 Å)