4D58
Focal Adhesion Kinase catalytic domain in complex with bis-anilino pyrimidine inhibitor
Summary for 4D58
Entry DOI | 10.2210/pdb4d58/pdb |
Related | 4D4R 4D4S 4D4V 4D4Y 4D55 4D5H 4D5K |
Descriptor | FOCAL ADHESION KINASE, SULFATE ION, 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE, ... (4 entities in total) |
Functional Keywords | transferase, kinase inhibitor, atp-binding, integrin signaling |
Biological source | GALLUS GALLUS (CHICKEN) |
Total number of polymer chains | 2 |
Total formula weight | 64220.74 |
Authors | Le Coq, J.,Lin, A.,Lietha, D. (deposition date: 2014-11-03, release date: 2015-02-18, Last modification date: 2023-12-20) |
Primary citation | Zhou, J.,Bronowska, A.,Le Coq, J.,Lietha, D.,Grater, F. Allosteric Regulation of Focal Adhesion Kinase by Pip2 and ATP. Biophys.J., 108:698-, 2015 Cited by PubMed: 25650936DOI: 10.1016/J.BPJ.2014.11.3454 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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