4D46

Crystal structure of E. coli FabI in complex with NAD and 5-bromo-2-(4-chloro-2-hydroxyphenoxy)benzonitrile

4D46 の概要

• エントリーDOI: 10.2210/pdb4d46/pdb
• 関連するPDBエントリー: 4D41 4D42 4D43 4D44 4D45
• 分子名称: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 5-bromo-2-(4-chloro-2-hydroxyphenoxy)benzonitrile, ... (4 entities in total)
• 機能のキーワード: enoyl-acp reductase, short-chain dehydrogenase/reductase superfamily, escherichia coli, fatty acid biosynthesis, lipid synthesis, ecfabi, fabi, oxidoreductase
• 由来する生物種: ESCHERICHIA COLI
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59904.10

構造登録者

Tareilus, M.,Schiebel, J.,Chang, A.,Tonge, P.J.,Sotriffer, C.A.,Kisker, C. (登録日: 2014-10-26, 公開日: 2015-03-04, 最終更新日: 2023-12-20)

• 主引用文献: Schiebel, J.,Chang, A.,Merget, B.,Bommineni, G.R.,Yu, W.,Spagnuolo, L.A.,Baxter, M.V.,Tareilus, M.,Tonge, P.J.,Kisker, C.,Sotriffer, C.A.; An Ordered Water Channel in Staphylococcus Aureus Fabi: Unraveling the Mechanism of Substrate Recognition and Reduction.; Biochemistry, 54:1943-, 2015; PubMed: 25706582; DOI: 10.1021/BI5014358

実験手法

X-RAY DIFFRACTION (2 Å)