4D3N

Structure of Bacillus subtilis Nitric Oxide Synthase in complex with 3-(2-(6-Amino-4-methylpyridin-2-yl)ethyl)-5-((2-(pyridin-2-yl)ethyl)amino)benzonitrile

4D3N の概要

• エントリーDOI: 10.2210/pdb4d3n/pdb
• 関連するPDBエントリー: 4D3I 4D3J 4D3K 4D3M 4D3O 4D3T 4D3U 4D3V
• 分子名称: NITRIC OXIDE SYNTHASE OXYGENASE, PROTOPORPHYRIN IX CONTAINING FE, 3-[2-(6-amino-4-methylpyridin-2-yl)ethyl]-5-{[2-(pyridin-2-yl)ethyl]amino}benzonitrile, ... (6 entities in total)
• 機能のキーワード: nitric oxide synthase, oxidoreductase, inhibitor
• 由来する生物種: BACILLUS SUBTILIS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43217.59

構造登録者

Holden, J.K.,Poulos, T.L. (登録日: 2014-10-23, 公開日: 2015-01-14, 最終更新日: 2023-12-20)

• 主引用文献: Holden, J.K.,Kang, S.,Hollingsworth, S.A.,Li, H.,Lim, N.,Chen, S.,Huang, H.,Xue, F.,Tang, W.,Silverman, R.B.,Poulos, T.L.; Structure-based design of bacterial nitric oxide synthase inhibitors.; J. Med. Chem., 58:994-1004, 2015; PubMed: 25522110; DOI: 10.1021/jm501723p

実験手法

X-RAY DIFFRACTION (2.13 Å)