4D33

Structure of bovine endothelial nitric oxide synthase heme domain in complex with (N1-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)-N2-(3- fluorophenethyl)ethane-1,2-diamine

Summary for 4D33

• Entry DOI: 10.2210/pdb4d33/pdb
• Related: 4D2Y 4D2Z 4D30 4D31 4D32 4D34 4D35 4D36 4D37 4D38 4D39 4D3A 4D3B 4V3U 4V3V 4V3W 4V3X 4V3Y 4V3Z
• Descriptor: NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (10 entities in total)
• Functional Keywords: oxidoreductase, nitric oxide synthase, inhibitor complex
• Biological source: BOS TAURUS (CATTLE)
• Cellular location: Cell membrane : P29473
• Total number of polymer chains: 2
• Total formula weight: 102424.43

Authors

Li, H.,Poulos, T.L. (deposition date: 2014-10-20, release date: 2014-12-24, Last modification date: 2015-03-04)

• Primary citation: Mukherjee, P.,Li, H.,Sevrioukova, I.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.; Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase.; J.Med.Chem., 58:1067-, 2015; PubMed: 25489882; DOI: 10.1021/JM501719E

Experimental method

X-RAY DIFFRACTION (2.087 Å)