4D11

GalNAc-T2 crystal soaked with UDP-5SGalNAc, mEA2 peptide and manganese (Lower resolution dataset)

Summary for 4D11

Entry DOI	10.2210/pdb4d11/pdb
Related	4D0T 4D0Z
Descriptor	POLYPEPTIDE GALNAC-TRANSFERASE T2, PEPTIDE, MANGANESE (II) ION, ... (6 entities in total)
Functional Keywords	transferase-peptide complex, retaining galnac-t2, substrate-guided sni-type reaction, qm/mm metadynamics, bi-bi kinetic mechanism, substrate specificity, acetamido group, transferase/peptide
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	11
Total formula weight	395424.98
Authors	Lira-Navarrete, E.,Iglesias-Fernandez, J.,Zandberg, W.F.,Companon, I.,Kong, Y.,Corzana, F.,Pinto, B.M.,Clausen, H.,Peregrina, J.M.,Vocadlo, D.,Rovira, C.,Hurtado-Guerrero, R. (deposition date: 2014-05-01, release date: 2014-05-28, Last modification date: 2023-12-20)
Primary citation	Lira-Navarrete, E.,Iglesias-Fernandez, J.,Zandberg, W.F.,Companon, I.,Kong, Y.,Corzana, F.,Pinto, B.M.,Clausen, H.,Peregrina, J.M.,Vocadlo, D.,Rovira, C.,Hurtado-Guerrero, R. Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N- Acetylgalactosaminyltransferase 2. Angew.Chem.Int.Ed.Engl., 53:8206-, 2014 Cited by PubMed: 24954443 DOI: 10.1002/ANIE.201402781 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation