4D0S

Mtb InhA complex with Pyradizinone compound 14

4D0S の概要

• エントリーDOI: 10.2210/pdb4d0s/pdb
• 関連するPDBエントリー: 4D0R
• 分子名称: ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1-{4-[(acetylamino)methyl]phenyl}-4-(4-chlorophenoxy)-6-oxo-1,6-dihydropyridazine-3-carboxamide, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, inha, acp enoyl reductase, methyl-thiazole
• 由来する生物種: MYCOBACTERIUM TUBERCULOSIS
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 118572.74

構造登録者

Read, J.A.,Breed, J.,Madhavapeddi, P.,Lange, S. (登録日: 2014-04-29, 公開日: 2015-05-20, 最終更新日: 2023-12-20)

• 主引用文献: Lange, S.; Pyridazinones: A Novel Scaffold with Excellent Physicochemical Properties and Safety Profile for a Clinically Validated Target of Mycobacterium Tuberculosis; To be Published,

実験手法

X-RAY DIFFRACTION (1.64 Å)