4CYU

Staphylococcus aureus 7,8-Dihydro-6-hydroxymethylpterin- pyrophosphokinase in complex with AMPCPP

4CYU の概要

• エントリーDOI: 10.2210/pdb4cyu/pdb
• 分子名称: 7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE, MAGNESIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... (6 entities in total)
• 機能のキーワード: transferase, s.aureus, folate, structure-based drug design
• 由来する生物種: STAPHYLOCOCCUS AUREUS; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 75674.96

構造登録者

Dennis, M.L.,Swarbrick, J.D.,Peat, T.S. (登録日: 2014-04-15, 公開日: 2015-01-28, 最終更新日: 2023-12-20)

• 主引用文献: Dennis, M.L.,Chhabra, S.,Wang, Z.,Debono, A.,Dolezal, O.,Newman, J.,Pitcher, N.P.,Rahmani, R.,Cleary, B.,Barlow, N.,Hattarki, M.,Graham, B.,Peat, T.S.,Baell, J.B.,Swarbrick, J.D.; Structure-Based Design and Development of Functionalized Mercaptoguanine Derivatives as Inhibitors of the Folate Biosynthesis Pathway Enzyme 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase from Staphylococcus Aureus.; J.Med.Chem., 57:9612-, 2014; PubMed: 25357262; DOI: 10.1021/JM501417F

実験手法

X-RAY DIFFRACTION (2.7 Å)