4CXW
Crystal structure of human FTO in complex with subfamily-selective inhibitor 12
Summary for 4CXW
Entry DOI | 10.2210/pdb4cxw/pdb |
Related | 4CXX 4CXY 4CXZ 4CY0 |
Descriptor | ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO, NICKEL (II) ION, (2E)-4-[N'-(4-benzyl-pyridine-3-carbonyl)-hydrazino]-4-oxo-but-2-enoic acid, ... (4 entities in total) |
Functional Keywords | oxidoreductase, small molecular probe |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus : Q9C0B1 |
Total number of polymer chains | 1 |
Total formula weight | 57207.06 |
Authors | Toh, D.W.,Sun, L.,Tan, J.,Chen, Y.,Lau, L.Z.M.,Hong, W.,Woon, E.C.Y.,Gao, Y.G. (deposition date: 2014-04-09, release date: 2014-10-01, Last modification date: 2023-12-20) |
Primary citation | Toh, J.D.W.,Sun, L.,Lau, L.Z.M.,Tan, J.,Low, J.J.A.,Tang, C.W.Q.,Cheong, E.J.Y.,Tan, M.J.H.,Chen, Y.,Hong, W.,Gao, Y.G.,Woon, E.C.Y. A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor ofN6-methyladenosine demethylase FTO. Chem Sci, 6:112-122, 2015 Cited by PubMed: 28553460DOI: 10.1039/c4sc02554g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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