4CXW

Crystal structure of human FTO in complex with subfamily-selective inhibitor 12

Summary for 4CXW

Entry DOI	10.2210/pdb4cxw/pdb
Related	4CXX 4CXY 4CXZ 4CY0
Descriptor	ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO, NICKEL (II) ION, (2E)-4-[N'-(4-benzyl-pyridine-3-carbonyl)-hydrazino]-4-oxo-but-2-enoic acid, ... (4 entities in total)
Functional Keywords	oxidoreductase, small molecular probe
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus : Q9C0B1
Total number of polymer chains	1
Total formula weight	57207.06
Authors	Toh, D.W.,Sun, L.,Tan, J.,Chen, Y.,Lau, L.Z.M.,Hong, W.,Woon, E.C.Y.,Gao, Y.G. (deposition date: 2014-04-09, release date: 2014-10-01, Last modification date: 2023-12-20)
Primary citation	Toh, J.D.W.,Sun, L.,Lau, L.Z.M.,Tan, J.,Low, J.J.A.,Tang, C.W.Q.,Cheong, E.J.Y.,Tan, M.J.H.,Chen, Y.,Hong, W.,Gao, Y.G.,Woon, E.C.Y. A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor ofN6-methyladenosine demethylase FTO. Chem Sci, 6:112-122, 2015 Cited by PubMed: 28553460 DOI: 10.1039/c4sc02554g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation