4CWF

Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor

4CWF の概要

関連するPDBエントリー4CWN 4CWO 4CWP 4CWQ 4CWR 4CWS 4CWT
分子名称HEAT SHOCK PROTEIN HSP 90-ALPHA, 5-propyl[1,2,4]triazolo[1,5-c]quinazolin-2-amine (3 entities in total)
機能のキーワードchaperone
由来する生物種HOMO SAPIENS (HUMAN)
細胞内の位置Cytoplasm  P07900
ポリマー鎖数1
分子量合計26038.2
構造登録者
主引用文献
Casale, E.,Amboldi, N.,Brasca, M.G.,Caronni, D.,Colombo, N.,Dalvit, C.,Felder, E.R.,Fogliatto, G.,Galvani, A.,Isacchi, A.,Polucci, P.,Riceputi, L.,Sola, F.,Visco, C.,Zuccotto, F.,Casuscelli, F.
Fragment-Based Hit Discovery and Structure-Based Optimization of Aminotriazoloquinazolines as Novel Hsp90 Inhibitors.
Bioorg.Med.Chem., 22:4135-, 2014
PubMed: 24980703 (主引用文献が同じPDBエントリー)
DOI: 10.1016/J.BMC.2014.05.056
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.234200.6%4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード